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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
13.33
Human Site:
S65
Identified Species:
24.44
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
S65
S
L
P
Q
R
K
T
S
R
S
R
V
Y
L
H
Chimpanzee
Pan troglodytes
XP_522169
734
81883
R83
A
G
A
R
R
V
Q
R
R
R
R
V
N
L
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
R95
A
G
A
R
R
A
Q
R
R
R
R
V
N
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
S65
S
L
P
Q
R
K
T
S
R
N
R
V
Y
L
H
Rat
Rattus norvegicus
P19686
690
77548
R65
H
P
Q
R
K
T
S
R
N
R
V
Y
L
H
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
S65
N
L
P
Q
R
K
T
S
R
S
R
V
Y
L
H
Chicken
Gallus gallus
XP_420375
688
77848
S65
P
Q
R
K
T
S
R
S
R
V
Y
L
H
T
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
S54
P
F
E
D
A
A
V
S
R
R
V
A
R
R
K
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
L65
S
S
R
A
K
V
N
L
H
T
L
G
E
S
I
Fruit Fly
Dros. melanogaster
Q07093
676
75644
L65
L
N
T
A
V
T
S
L
V
A
K
Y
R
Q
N
Honey Bee
Apis mellifera
NP_001011650
699
78655
N65
A
E
D
T
Q
T
L
N
L
K
H
L
R
A
A
Nematode Worm
Caenorhab. elegans
O02298
688
78384
F73
I
W
E
A
Y
G
G
F
L
I
Q
F
T
M
E
Sea Urchin
Strong. purpuratus
P16065
1125
126238
T238
I
Q
R
T
K
E
T
T
R
I
Y
V
F
F
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
33.3
N.A.
33.3
N.A.
93.3
0
N.A.
93.3
13.3
N.A.
13.3
6.6
0
0
0
20
P-Site Similarity:
100
46.6
N.A.
46.6
N.A.
100
20
N.A.
100
33.3
N.A.
13.3
20
26.6
26.6
13.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
16
24
8
16
0
0
0
8
0
8
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
16
% D
% Glu:
0
8
16
0
0
8
0
0
0
0
0
0
8
0
8
% E
% Phe:
0
8
0
0
0
0
0
8
0
0
0
8
8
8
0
% F
% Gly:
0
16
0
0
0
8
8
0
0
0
0
8
0
0
8
% G
% His:
8
0
0
0
0
0
0
0
8
0
8
0
8
8
24
% H
% Ile:
16
0
0
0
0
0
0
0
0
16
0
0
0
0
8
% I
% Lys:
0
0
0
8
24
24
0
0
0
8
8
0
0
0
8
% K
% Leu:
8
24
0
0
0
0
8
16
16
0
8
16
8
39
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
8
0
0
0
0
8
8
8
8
0
0
16
0
8
% N
% Pro:
16
8
24
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
16
8
24
8
0
16
0
0
0
8
0
0
8
0
% Q
% Arg:
0
0
24
24
39
0
8
24
62
31
39
0
24
8
0
% R
% Ser:
24
8
0
0
0
8
16
39
0
16
0
0
0
8
0
% S
% Thr:
0
0
8
16
8
24
31
8
0
8
0
0
8
8
8
% T
% Val:
0
0
0
0
8
16
8
0
8
8
16
47
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
16
16
24
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _